Regulatory T-cell heterogeneity and the cancer immune response
نویسندگان
چکیده
منابع مشابه
Regulatory T-cell heterogeneity and the cancer immune response
The frequency of circulating or tumour-infiltrating regulatory T cells (Tregs) has been associated with poor patient survival in many cancers including breast, melanoma and lung. It has been hypothesised that Tregs impact the anti-tumour function of effector T cells, resulting in worse outcomes for patients. However, high infiltrates of Tregs have been associated with a positive outcome of pati...
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Regulatory T cells (Tregs) preserve immune homeostasis by suppressing autoimmunity and inflammation. While most Tregs develop in the thymus, they are heterogenous in their tissue localisation and function. This heterogeneity is advantageous for the maintenance of immune and tissue homeostasis in organs such as gut and kidney but often detrimental in the context of tumor, since Treg cells can da...
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ژورنال
عنوان ژورنال: Clinical & Translational Immunology
سال: 2017
ISSN: 2050-0068
DOI: 10.1038/cti.2017.43